The capital of the Urals — the Church on the Blood on the site where the Romanovs were killed, the Yeltsin Center and the border between Europe and Asia.
The capital of the Urals is a rare case in Russia of a city that is interesting not for individual "sights" but for its urban fabric itself: working factories stand next to museums of international quality, and constructivist blocks of the 1930s are interspersed with merchant mansions. Two days is an honest minimum: in that time the centre can be walked, leaving an evening for the bars and half a day for a trip out of town.
Koltsovo Airport is a major hub with direct flights from most Russian cities and some abroad. It is about half an hour to the centre: city buses and shared minibuses run to the railway station, and there are taxis, inexpensive by Moscow standards. At night a taxi is the most convenient.
The railway is one of the city's strengths: it sits on the Trans-Siberian and trains run constantly in both directions. From Moscow it is roughly 24 hours, with fast named services available. It makes sense to build Yekaterinburg into a route running Moscow – Kazan – Yekaterinburg – Tyumen/Tobolsk and on eastwards.
Within the city: there is a metro, only one line running north to south, but it genuinely helps — it links the station, the centre and Uralmash. Payment is by card at the turnstile. Otherwise there are trams, trolleybuses and buses, and city apps show transport in real time. But the main thing is that the historic centre is compact and can be walked in its entirety; transport is only needed for trips to Uralmash, VIZ and out of town.
Accommodation is generally cheaper than in the capital; there are plenty of hostels and apartments, and prices jump in summer and during major trade fairs, so book ahead.
Two days are enough: the first for the Red Line, the Plotinka, the Church on the Blood and the Yeltsin Center; the second for the constructivism and a trip to Ganina Yama with the Europe–Asia border. A third day is justified if the industrial theme interests you — Nevyansk with its leaning tower, Nizhny Tagil, or the Olenyi Ruchyi nature park.
The best time is late May to September. Summer is warm but changeable: rain and sharp cold snaps are normal, so a raincoat is essential. Winter is a proper Ural one, down to −25 °C and below; you can come and the city functions, but walking round the constructivism will be hard going. The shoulder seasons are mud and greyness, the worst option.
Prices are noticeably lower than in Moscow: set business lunches in the centre are cheap and the coffee shops are good and inexpensive. Essential to try are Ural pelmeni (here it is food, not a brand), posikunchiki (small fried meat pasties), shangi (open-topped pastries), and anything involving local fish and mushrooms. There is a developed third-wave coffee and craft bar scene — the city is lively in the evenings, especially around Lenin Avenue and Vainera.
Safety is normal for a large Russian city: the centre is calm, and late at night it is worth avoiding outlying industrial zones and dark courtyards. One particular point is the roads: cross at pedestrian crossings carefully here, as drivers do not always give way.